PDRN (Polydeoxyribonucleotide)
This document is technical information about materials. It does not recommend any procedure or product.
In brief
A mixture of DNA-derived polymer fragments, typically of marine origin, used in wound and skin applications. Distinct from the polymer biostimulators in that it is not a particulate scaffold.
Regulatory identity by market
COS cosmetic · MD medical device · RX drug · — not established in public sources
Identity & physical properties
| Synonyms | Polydeoxyribonucleotide, PDRN, Polynucleotide (related class) |
|---|---|
| Family | Nucleotide-derived agent |
Mechanism
Reviews describe adenosine A2A receptor engagement and salvage-pathway activity. Laboratory work has reported effects on autophagy and SIRT1 in skin ageing models.
Evidence
Regulatory identity — detail
| Market | Classification | Note | Basis |
|---|---|---|---|
| KR | unclassified | Unlike the particulate biostimulators on this site, nucleotide-derived agents are marketed in more than one regulatory lane, and the route differs with presentation and intended use. A single classification could not be established from public sources as of the revision date below; settling it requires product-level records from the national authority. | — |
| EU | unclassified | Public sources describe both nationally authorised medicinal products and CE-marked devices containing nucleotide-derived agents, so no single classification holds across the market. Not established as of the revision date below. | — |
| US | unclassified | Public sources distinguish topical products marketed as cosmetics from injectable use, which is described as not FDA-approved. A single material-level classification could not be established as of the revision date below. | — |
| JP | unclassified | Not established from public sources as of the revision date below. | — |
| CN | unclassified | Not established from public sources as of the revision date below. | — |
| VN | unclassified | Not established from public sources as of the revision date below. | — |
Limitations & open questions
Source material and degree of purification differ between products, and the literature does not always specify which. Marine origin raises allergen questions that are not consistently addressed.
All statements on this page are drawn from the cited literature. Where a market’s regulatory classification could not be established from public sources, it is marked as not established rather than inferred.